Emergency teams responded to the scene of a rollover on Highway 4, ten kilometres north of Swift Current shortly after noon on Monday.
A tractor trailer hauling powder uranium was the lone vehicle involved in the incident.
A HAZMAT team has been requested.
Law enforcement says there are no residences downwind from the scene of the collision and no evacuations have been ordered.
All farms within a 1.6 kilometre radius have been notified of the spill. No injuries have been reported.
Traffic in the area is being re-routed and delays are expected.