Beginning Wednesday, Elphinstone Street, from Saskatchewan Drive to 10th Avenue will be closed for rail repairs for 2 days.
Motorists who use this route regularly likely have noticed signs warning of the closure.
However, it is advised motorists consider another route to avoid contributing to traffic congestion.
In the meantime, the city of Regina says Elphinstone is not the only street to be affected by a road closure.
Winnipeg Street, from 15th Avenue to 14th Avenue, will be closed for tree pruning for one and a half days beginning Tuesday.