RCMP are reporting one fatality resulting from a crash which closed Highway 39 for almost seven hours on Friday afternoon.
Emergency services were called to a two vehicle collision just north west of Weyburn just before 2 p.m.
A Dodge pickup truck and a semi-trailer were involved in a head on incident.
The driver of the pickup was killed, while the lone occupant of the semi was treated on scene with minor injuries.
No one else was injured.
RCMP Traffic Services closed the Highway until 9 p.m. as traffic re-constructionists worked on identifying the cause of the collision.
The investigation into the incident continues.