Highway 2 was blocked on Friday due to an overturned fuel truck and diesel spill in the Meacham area.
RCMP say the driver of the semi was the lone occupant.
He was transported to hospital by STARS with undetermined injuries.
As of 5pm on Friday, the highway remained blocked for a 2 mile radius around the accident site so Sask Environment could work on the cleanup of the spill.
No evacuations were needed and there are no buildings in the immediate vicinity.