Saskatoon RCMP, as well as Colonsay Fire and EMS responded to what turned out to be a fatal two-vehicle collision on Highway 16 east of Colonsay.
On Wednesday evening, just after 8:30, an east-bound pickup truck collided with a west-bound pickup, killing both drivers.
The drivers were the lone occupants of their vehicles, and their names are not being released.
The highway was restricted for several hours while the investigation is underway, but it has since been reopened.
RCMP and the Office of the Chief Coroner are continuing their investigation.