Moose Jaw RCMP were forced to close the Trans-Canada between there and Regina on Thursday around 4:00 p.m. after a 15 car pile up just west of Belle Plaine.
Road conditions quickly turned dangerous thanks to strong wind gusts, which created poor visibility and icy road surfaces.
Police also said they responded to an accident on Highway 6 about 25 kilometers south of Regina around 7:45 p.m. Thursday night, and again asked motorists to stay off the highways if possible.
There is no word yet on the number of injuries in either accident.
Both highways are open Friday morning, but are still reporting winter driving conditions.