RCMP say a 30 and 66-year-old man are dead, after their vehicles collided on Highway 2 just north of Prince Albert on Sunday evening.
Police were called to the scene around 8:00 p.m.
A southbound pickup driven by the 30 year-old man from the Little Red River First Nation is said to have crossed over into the northbound lanes of the highway before colliding with an SUV being driven by the 66-year-old man who was from Christopher Lake.
Police say a 62-year-old woman who was a passenger in the SUV was also taken to hospital with multiple injuries.
The investigation is on-going.