CN Rail says a loaded westbound grain train derailed just west of Landis around 8:15 a.m. Wednesday morning.
Spokesman Patrick Waldron says forty hopper cars derailed.
There are no injuries and no dangerous goods are involved.
CN crews are cleaning up the scene and investigating the cause of the crash.
The rail line west of Saskatoon is closed to through traffic.
Landis is about 400 kilometers northwest of Regina.