White Butte RCMP are saying the collision they attended to Thursday night on highway 6 was a fatal.
RCMP attended the scene about seven and a half kilometres south of Regina, where four vehicles were involved in the collision.
It is believed the initial collision occurred between a north bound truck and south bound van head-on, with the truck bouncing into the ditch and the van then hitting another two vehicles.
Two people, the 78 year-old driver of the van and the 83 year old driver of the truck, were pronounced dead at the scene.
Three people in the other two vehicles did not suffer any serious injuries.