RCMP, EMS and Balgonie Fire Department are currently on the scene of the collision between a train and a SUV.
RCMP say the southbound SUV collided with the train as the it was crossing the 640 grid, just northwest of Edenwold.
There were five people in the vehicle.
Four have injuries, one is seriously injured.
All five people are being transported to hospital.
RCMP are on scene, but the investigation will fall to the CN police as soon as they arrive.