The advisory are in effect for Swift Current, Shaunavon, Kindersely, Rosetown, Leader and their surrounding areas.
Environment Canada says the low temperatures are caused by a ridge of high pressure coming in from Alberta, which will clear out any cloud cover and decrease wind speeds in the impacted areas.
A warmer air mass coming into the province will keep temperatures above the freezing mark.
The weather office says any frost-prone plants should be covered if possible.
Regina is not under a frost advisory.